Increased Interleukin-27 Promotes Th1 Differentiation in Patients with Chronic Immune Thrombocytopenia
نویسندگان
چکیده
منابع مشابه
TLR7 promotes Th1 polarization in immune thrombocytopenia.
INTRODUCTION T helper 1 cell (Th1) polarization persists in the autoimmune response found in immune thrombocytopenia (ITP). Toll-like receptor 7 (TLR7) expression, which also plays an important role in autoimmune diseases, was verified to increase in ITP. However, the exact role of TLR7 in ITP is not well elucidated. Here, we explored the hypothesis that TLR7 participates in the pathophysiology...
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Biostatistics and Epidemiology, University of Oklahoma Health Sciences Center, Oklahoma City; New York Presbyterian Hospital, Departments of Pediatrics and Medicine, Division of Hematology, New York; Cancer Care Centers of South Texas/ US Oncology, San Antonio, Texas; 4 Jane Ann Nohl, Division of Hematology, University of Southern California Keck School of Medicine, Los Angeles; University of P...
متن کاملInterleukin 27 inhibits cytotoxic T-lymphocyte-mediated platelet destruction in primary immune thrombocytopenia.
Cytotoxic T-lymphocyte (CTL)-mediated platelet destruction and aberrant cytokine profiles play important roles in the pathogenesis of primary immune thrombocytopenia (ITP). Interleukin-27 (IL-27) has pleiotropic immunomodulatory effects. However, the effect of IL-27 on CTL activity in ITP has not been reported. In the present study, platelets from ITP patients were cultured with autologous CTLs...
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OBJECTIVE IL-27 is an immunomodulatory cytokine with potent anti-HIV properties in PBMCs, CD4+ T cells, macrophages and immature dendritic cells. Previous smaller studies have suggested that HIV-1 infection may alter IL-27 and influence HIV-1 pathogenesis. The aim of this study was to examine the relationship between plasma IL-27 levels in a well-characterised cohort of HIV-1 infected patients....
متن کاملIncreased IL-17A but Decreased IL-27 Serum Levels in Patients with Multiple Sclerosis
Background: Effector CD4+ T cell subsets play an important role in Multiple Sclerosis (MS). Interleukin-27 (IL-27) suppresses Th (Th1, Th2 and Th17) cells and dampens autoimmunity and tissue inflammation by promoting the generation of Type 1 regulatory T cells (Tr1). Objective: To identify the relative levels of IL-27 and IL-17A in MS disease. Method: In a case-control study, venous blood was c...
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ژورنال
عنوان ژورنال: Scandinavian Journal of Immunology
سال: 2014
ISSN: 0300-9475
DOI: 10.1111/sji.12197